![]() They also assessed the drug’s safety and tolerability. Researchers compared overall outcomes, as well as differences between mydriatic agents and by iris color. The secondary outcomes were the percentage of subjects returning to baseline PD at 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours and 24 hours. The primary endpoint of the study was the percentage of subjects returning to within 0.2 mm of their baseline pupil diameter (PD) at 90 minutes. All subjects first received one of three mydriatic agents before receiving either phentolamine drops, 94 subjects, or placebo, 91 subjects. Researchers explored the efficacy and safety of the drug in a randomized, parallel-arm, double-masked phase 3 trial comprising 185 healthy individuals aged 12 years and older. Phentolamine interacts directly with the dilator muscle of the iris as opposed to cholinergic drugs, which interact with the sphincter muscle. It would be great, I think, to have a drop that could speed up reversal of mydriasis, and perhaps this could be offered to patients as an option.” Jay S. Some of these dilating drops can last 6 to 8 hours. ![]() “They want to get back to work if they’re dilated earlier in the day. “We know the impact on these patients in terms of glare and visual changes, and it’s problematic,” he said. Pepose, MD, PhD, told Ocular Surgery News that Nyxol (phentolamine mesylate ophthalmic solution 1%, Ocuphire) could present a unique treatment for patients following any of the 100 million yearly dilated eye exams in the United States every year. Nyxol, an alpha 1/2 antagonist eye drop, helped reverse the effects of pharmacologically induced mydriasis in healthy subjects, according to a phase 3 study. If you continue to have this issue please contact to Healio
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |